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KMID : 0352519850220010489
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Korea Univercity Medical Journal
1985 Volume.22 No. 1 p.489 ~ p.502
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An Experimental Study on the Effects of Infiltration of the Penicillin, Chymotrypsin, and Oradexon into the Tendon Sheath
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Kim Heung-Kee
Lee Hong-Kun
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Abstract
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Functional restoration of surgically repaired tendons, particularly in the hand, have frequently been unsatisfactory because of the formation of peritendinous adhesions which impede smooth gliding motion of the tendon.
Numerous materials and drugs have been used to lessen the formation of peritendinous adhesions without interfering tendon healing.
Author have made an experimental study with penicillin, chymotrypsin and oradexon infiltrated along the repaired tendon of adult rabbits and observed the nature and extent of peritendinous adhesion. Forty rabbits were divided into four groups, each comprised 10 rabbits. In group I, tendon and tendon sheath were cut and closed after author´s modification of Bunnell´s tendon suture of divided flexor digitorum longus as control, and penicillin infiltrated in group Ⅱ, chymotrypsin in group Ⅲ, oradexon in group Ⅳ, respectively after the same method of repair.
The results obtained are as follows:
1. In all the groups, the healing of the cut tendon were established in the dual mechanisms; The one is the proliferation of the fibrovascular tissue from the tendon sheath and the other is the regeneration of tenocytes of the tendon itself.
2. The evidence of the adhesion between tendon and tendon sheath was displayed from the postoperative 2 weeks in all groups and continued to display to the postoperative 6 weeks in the group of suture only and the penicillin injected group, but disappeared at the postoperative 6 weeks in the chymotrypsin injected group and at the postoperative 4 weeks in the oradexon injected group.
The effect in the prevention of the adhesion was most remarkable in the oradexon injected group and was the next in the penicillin injected group.
3. The regeneration by the tenocytes of the cut tendon were noticed from the postoperative 4 weeks in the group of suture only and the penicillin injected group, while the regeneration were noticed from the postoperative 3 weeks in the oradexon injected group and the chymotrypsin injected group, so that chymotrypsin and oradexon were seemed to be favorable in the regeneration of the tenocytes.
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